Neuroanatomy and Behaviour

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Keywords

Animal research
Ethics
Government
Refinement
Housing
Transport
Stress

How to Cite

Khoo, S. Y.-S., Kendig, M. D., & Bradfield, L. A. (2022). Animal research is saving lives, but funding is needed to improve welfare: Submission to the New South Wales parliamentary inquiry. Neuroanatomy and Behaviour, 4, e45. https://doi.org/10.35430/nab.2022.e45

Abstract

Many kinds of animal research are occurring in New South Wales (NSW), with biomedical research among the most prominent. As behavioural neuroscientists, we study the neural mechanisms of motivation and cognition in rodents, which is important for developing new treatments for a range of psychological disorders, such as substance use disorder, as well as neurodegenerative diseases such as Alzheimer’s. The welfare and wellbeing of the animals we study is of critical importance, not only to ensure the quality of our data but to our sense of morality as compassionate human beings. Biomedical animal research is highly regulated and the pharmacological and biological tools we use pose negligible risks to the public. Meanwhile, our research brings enormous benefits to NSW by building expertise and supporting biotechnology companies. Although research on complex behaviours cannot be replaced by non-animal procedures, we believe that there is much scope for refinement and improvement in animal welfare in NSW. For example, investing in a local breeding facility to produce animals used in NSW research projects would significantly reduce the stress associated with importing animals from interstate or overseas. Additionally, standard animal housing could be improved through targeted and ongoing investment to refit animal facilities and support additional caretaker and veterinary staff to provide higher degrees of welfare.

https://doi.org/10.35430/nab.2022.e45
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References

Portfolio Committee No 2 - Health. Media release: New parliamentary inquiry into the use of primates and other animals in medical research in NSW; 2022 [cited 2022-02-01]. Available from: https://www.parliament.nsw.gov.au/lcdocs/other/16595/Media%20release%20-%20PC2%20-%20New%20Inquiry%20into%20animal%20medical%20research.pdf. Archived: https://www.parliament.nsw.gov.au/lcdocs/other/16595/Media%20release%20-%20PC2%20-%20New%20Inquiry%20into%20animal%20medical%20research.pdf.

Portfolio Committee No 2 - Health. Inquiry into the use of primates and other animals in medical research in New South Wales: Terms of reference; 2022 [cited 2022-02-17].Available from: https://www.parliament.nsw.gov.au/lcdocs/inquiries/2857/Terms%20of%20Reference%20-%20PC%202%20-%20Medical%20research%20on%20animals.pdf. Archived: https://www.parliament.nsw.gov.au/lcdocs/inquiries/2857/Terms%20of%20Reference%20-%20PC%202%20-%20Medical%20research%20on%20animals.pdf.

Chan JFW, Yuan S, Zhang AJ, Poon VKM, Chan CCS, Lee ACY, et al. Surgical mask partition reduces the risk of noncontact transmission in a golden syrian hamster model for coronavirus disease 2019 (COVID-19). Clinical Infectious Diseases. 2020;71(16):2139–2149. doi: 10.1093/cid/ciaa644.

Health Protection NSW. COVID-19 vaccination in NSW (18 March 2022); 2022 [cited 2022-03-20]. Available from: https://www.health.nsw.gov.au/Infectious/covid-19/vaccine/Pages/default.aspx. Archived: https://www.health.nsw.gov.au/Infectious/covid-19/vaccine/Pages/default.aspx.

Pfizer, BioNTech. Pfizer and BioNTech announce data from preclinical studies of mRNA-based vaccine candidate against COVID-19; 2020 [cited 2022-03-07]. Available from: https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-announce-data-preclinical-studies-mrna. Archived: https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-announce-data-preclinical-studies-mrna.

Waltz E. Omicron-targeted vaccines do no better than original jabs in early tests. Nature. 2022;doi: 10.1038/d41586-022-00003-y.

Norton JN, Reynolds RP, Chan C, Valdivia RH, Staats HF.Assessing the satisfaction and burden within an academic animal care and use program. The FASEB Journal. 2017;31(9):3913–3921. doi: 10.1096/fj.201700072RR.

Pritt S, McNulty JA, Greene M, Light S, Brown M. Decreasing institutionally imposed regulatory burden for animal research. Lab Animal. 2017;45(8):297–300. doi: 10.1038/laban.1067.

Thulin JD, Bradfield JF, Bergdall VK, Conour LA, Grady AW, Hickman DL, et al. The cost of self-imposed regulatory burden in animal research. The FASEB Journal. 2014;28(8):3297–3300. doi: 10.1096/fj.14-254094.

Mallapaty S. Loss of Australia’s largest lab animal supplier will leave ’huge gap’. Nature. 2021;doi: 10.1038/d41586-021-01896-x.

Capdevila S, Giral M, Ruiz de la Torre JL, Russell RJ, Kramer K. Acclimatization of rats after ground transportation to a new animal facility. Laboratory Animals. 2007;41(2):255–261. doi: 10.1258/002367707780378096.

National centre for the replacement refinement & reduction of animals in research; 2022 [cited 2022-03-08]. Available from: https://www.nc3rs.org.uk/. Archived: https://www.nc3rs.org.uk/.

Makowska IJ, Weary DM. The importance of burrowing, climbing and standing upright for laboratory rats. Royal Society Open Science. 2016;3(6):160136. doi: 10.1098/rsos.160136.

Khoo SYS, Lay BPP, Joya J, McNally GP. Local anaesthetic refinement of pentobarbital euthanasia reduces abdominal writhing without affecting immunohistochemical endpoints in rats. Laboratory Animals. 2018;52(2):152–162. doi: 10.1177/0023677217721260.

Khoo SYS, Correia V, Uhrig A. Nesting material enrichment reduces severity of overgrooming-related self-injury in individually housed rats. Laboratory Animals. 2020;54(6):546–558. doi: 10.1177/0023677219894356.

Revill J. Swiss reject ban on animal testing in referendum; 2022 [cited 2022-03-10]. Available from: https://www.reuters.com/world/europe/switzerland-vote-becoming-first-nation-ban-animal-testing-2022-02-13/. Archived: https://www.reuters.com/world/europe/switzerland-votebecoming-first-nation-ban-animal-testing-2022-02-13/

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